A clinical trial for Psoriatic Arthritis
This clinical trial is testing an investigational medicine in people who have active psoriatic arthritis.
About This Clinical Trial
Why is this trial being done?
Researchers are testing an investigational medicine called tulisokibart in people diagnosed with psoriatic arthritis (PsA).
Researchers will compare the investigational medicine, tulisokibart, to a placebo, which looks like the investigational medicine but contains no active ingredients. This trial is trying to find out if the investigational medicine is safe and how well it may work in resolving or improving PsA symptoms compared to a placebo. The investigational medicine is experimental. It has not been approved to treat PsA.
Trial Overview
Trial Purpose
Researchers are studying an investigational medicine called tulisokibart (MK-7240) to see whether it may help improve symptoms of active PsA. The study aims to determine the efficacy, safety, and tolerability of tulisokibart in adult participants with active PsA.
In this study, researchers will look at different doses of tulisokibart. Researchers want to learn if at least one of the study doses of tulisokibart works better than a placebo to lessen PsA symptoms. A placebo looks like the investigational medicine but has none in it. Using a placebo helps researchers better understand the effects of the investigational medicine.
View full trial information on ClinicalTrials.gov
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National Trial Reference NumberNational Trial Reference NumberA unique identification code given to each clinical trial record registered on ClinicalTrials.gov. Also called the ClinicalTrials.gov identifier. | NCT07486960 |
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Merck Protocol ID |
MK-7240-015 |
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Conditions |
Psoriatic Arthritis |
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Age Range |
18 to 80 years |
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SexSexSex assigned at birth. Sex is distinct from gender-based eligibility. | Male and Female |
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Trial PhaseTrial PhaseThe stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the trial’s objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions. | 2 |
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Start Date End Date |
2026-04-20 2030-01-11 |
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Downloads |
Trial Details
Patient Participation
Only a qualified healthcare professional can determine if you are eligible to take part in a clinical trial.
Conditions
Psoriatic Arthritis
Trial Phase 2
In Phase 2 trials, researchers try to find out if a treatment works in about 100 to 500 participantsResearch participantIn clinical research, a person who qualifies and agrees to participate in a study. Also called volunteer, trial participant. – usually people who have the health condition the treatment is intended to treat. In vaccine trials, the participants are usually healthy. Phase 2 trials may happen in a doctor’s office, a clinic, or a hospital.
Who can join this trial?
You may be able to join this trial if you:
- Have received a diagnosis of PsA at least 6 months before the study Screening Period
- Have at least 3 tender joints and 3 swollen joints
- Do not have a skin condition diagnosis other than psoriasis
- Do not have an arthritis diagnosis that began before age 17 or a current diagnosis of inflammatory joint disease other than PsA
You and your trial doctor will discuss if this trial is a good option for you, as well as the possible benefits and risks of joining this trial.
Trial Locations
Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.
How to read clinical trials
When you start your search for a clinical trial, it’s important to gather as much information as you can. We’ve created a guide to help you understand the information you will see in your clinical trial search results.
Commitment to patient safety
Taking part in a clinical trial is a process. We’ve outlined the steps you can expect before, during, and after being in a clinical trial.
Frequently Asked Questions
About the MK-7240-015 clinical trial
This trial is trying to find out if the investigational medicine, tulisokibart, is safe and how well it may work in resolving or improving PsA symptoms compared to a placebo.
Before you agree to participate, the trial team will review all aspects of the clinical trial with you. If you decide to take part, you will be given a document called an Informed Consent FormInformed Consent form (IC)A document that provides information about the purpose of the study, possible risks and benefits, and the participant’s rights and responsibilities. Signing the consent form means that the person agrees to participate in the research; A document used to explain the details of a study (clinical trial) that provides, in writing, the clinical trial’s purpose, assessments, procedures, potential benefits and risks, and precautions. You will have the opportunity to ask questions to decide if participating is right for you.
Privacy, withdrawing, costs, and permission
The study team respects and protects your privacy and will not share your information, except as required by law, and will store your personal information with codes that do not identify you. The Informed Consent FormInformed Consent form (IC)A document that provides information about the purpose of the study, possible risks and benefits, and the participant’s rights and responsibilities. Signing the consent form means that the person agrees to participate in the research; A document used to explain the details of a study (clinical trial) (completed by you prior to participation) will provide more information about how your privacy will be maintained.
Your participation in the clinical trial is entirely voluntary and you may withdraw for any reason, at any time. If you do decide to withdraw early, you will be asked to notify the study team before doing so. You will be asked to return to the study site at least once to complete a final visit and return any unused drug.
No, your doctor does not have to give permission for you to participate. However, either you or the study doctor, with your permission, may contact your personal doctor to discuss your participation before you begin and keep your doctor up to date about your progress.
About clinical trials
A clinical trial tries to answer questions about how medicines work in the people who take them. Researchers run studies to test whether an investigational medicine is safe and effective. These studies may help doctors find new ways to help prevent, detect, or treat health problems.
Participant safety is the priority. There are rules in place to help protect the rights, safety, and well-being of people who volunteer for clinical trials. These rules are put in place to make sure clinical trials follow strict scientific and ethical guidelines.
Before a clinical trial can begin, a review board or ethics committee must review the clinical trial. In the United States, this group is called an IRB or Institutional Review Board. An IRB is made up of doctors, scientists, and other members of the community.
Only people who meet all eligibility criteria for a clinical trial may take part. The trial team at the site you select will review your medical history and current medical status against the eligibility criteria. They will determine if you are eligible to participate. You may also be asked to provide information from your medical records to help the trial team determine whether you may be eligible.
An investigational medicine is a drug that hasn’t yet been approved for use in the general public. In order for it to be approved, the investigational medicine must be tested in clinical trials to see if it is safe and effective for treating the target disease in certain groups of people.
A placebo is a material that looks like the investigational medicine but does not contain any active medicine. Researchers use a placebo to see if the investigational medicine works better or is safer than taking nothing. Because a placebo is being used in this trial, there is a chance that you will receive one.
If you are eligible and choose to participate, the trial staff will be available to answer any questions you may have.
Understanding clinical trials is important when making a decision about joining one. To see more Frequently Asked Questions, click on the link below.
What can you do next?
If you think this clinical trial might be a good fit and you are interested in taking part, take the next step to see if you are eligible.
Discuss with your doctor or research team
Print this page with details about the trial or email it to your doctor to discuss the clinical trial during your next visit.
To learn more, call 1-888-577-8839