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Search Keyword: Endocrine Gland Neoplasms

This is a study to evaluate the efficacy and safety of belzutifan monotherapy in participants with advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET), von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Advanced Solid Tumors With hypoxia inducible factor-2 alpha (HIF-2α) related genetic alterations. The primary objective of the study is to evaluate the objective response rate (ORR) of belzutifan per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by blinded independent central review (BICR).

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor, or Von Hippel-Lindau Disease-Associated Tumors

October 9, 2022

By clique_admin

This is a study to evaluate the efficacy and safety of belzutifan monotherapy in participants with advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET), von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal

MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors

October 9, 2022

By clique_admin

The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of pembrolizumab/vibostolimab co-formulation (MK-7684A) with or without other anticancer therapies in participants with selected advanced solid tumors.

Pembrolizumab With Chemotherapy and MK-4830 for Treating Participants With Ovarian Cancer

October 9, 2022

By clique_admin

The primary objective is to evaluate in participants with high-grade serous ovarian cancer (HGSOC), whether the reduction from baseline in circulating tumor DNA (ctDNA) at Cycle 3 (ΔctDNA) is larger in

Study of Pembrolizumab in Participants With Advanced Solid Tumors

October 9, 2022

By clique_admin

In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).

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