Conditions
Cutaneous Squamous Cell Carcinoma, Endometrial Cancer, Solid Tumor
The purpose of this study is to evaluate pathologic complete response (pCR) rate of coformulated favezelimab/pembrolizumab (MK-4280A) or pembrolizumab as assessed by blinded central pathology review (BICR) in participants with cutaneous squamous cell carcinoma (cSCC) [Cohort A] and to evaluate lenvatinib in combination with coformulated favezelimab/pembrolizumab or pembrolizumab with respect to objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by investigator in participants proficient in mismatch repair (pMMR) endometrial cancer (EC) [Cohort B].
NATIONAL TRIAL REFERENCE NUMBER
NCT06036836
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Conditions
Cutaneous Squamous Cell Carcinoma, Endometrial Cancer, Solid Tumor
Age Range
18+
Sex
All
All patients who enroll in the trial will receive medication while on the study.
50% will receive MK-4280A (contains favezelimab and pembrolizumab) before and after surgery.
50% will receive pembrolizumab before and after surgery.
50% will receive MK-4280A (contains favezelimab and pembrolizumab) and lenvatinib.
50% will receive pembrolizumab and lenvatinib.
In Phase 2 trials, researchers try to find out if a treatment works in about 100 to 500 participants – usually people who have the health condition the treatment is intended to treat. In vaccine trials, the participants are usually healthy. Phase 2 trials may happen in a doctor’s office, a clinic, or a hospital.
Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.
If you think this clinical trial might be a good fit and you are interested in taking part, take the next step to see if you are eligible.
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